Tissue Pulverizer / Shaker Mill

The SPEX SamplePrep Model 2000 Geno/Grinder is a new laboratory mill specifically designed for vigorous up-and-down shaking of deep-well titer plates. It is typically used to prepare tissue for extractions of nucleic acid, protein, and other constituents by shaking the tissue, steel balls, and a buffering agent together in each well of the titer plate. The Geno/Grinder measures less than two cubic feet and weighs 110 pounds. It meets all European CE Directives and is available in either 115V/60Hz or 230V/50Hz models. The operator can precisely adjust the stroke rate of the sample clamp mech-anism anywhere from 500 to 2000 up-and-down cycles per minute. The Geno/Grinder is specifically designed for shaking titer plates, and has many advantages over conventional mills and paint shakers "adapted" for this purpose.

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Cryogenic Grinding

Cryogenic grinding of plant and animal tissue is a very effective technique for the Microbiologist. Samples that require extraction of nucleic acids must be kept at -80 ºC or lower during the entire extraction process. Utilizing SPEX SamplePrep Freezer/Mills will maintain the sample temperatures well below these critical temperatures during the automated grinding sequence. For samples that are soft or flexible at room temperature, cryogenic grinding may be the only viable technique for processing your samples. A detailed explanation of the various cryogenic techniques can be found in Section II, Chapter 2, beginning on page 125 of this Handbook.

SPEX SamplePrep Freezer/Mills are cryogenic laboratory mills which chill samples in liquid nitrogen and pulverize them with a magnetically driven impactor. Each sample is placed in a separate grinding vial which is immersed in a liquid nitrogen bath inside the mill. Thus there is no cross-sample contamination, and the low temperature of the sample is maintained during grinding. These features have made the SPEX Freezer/Mill the most effective in the world, the “mill of last resort ” for many normally ungrindable samples. Freezer/Mill technology, field-proven since the 1960s, has been built into two new models, the 6750 and 6850 Freezer/Mills. Both include significant safety features, and electronic controls which allow an entire grinding sequence to be programmed.